The multi-talented podocyte

The highly talented child.

either before or during the period of immunosuppression does not necessarily confer protection. This is illustrated by two of our patients. Case reports Case 1. A boy, aged 3 years 5 months, first presented with a history of a progressive petechial rash. Physical examination showed pallor, bruising, and hepatosplenomegaly. A bone marrow aspirate confirmed a diagnosis of acute lymphoblastic leuk...

MECP2, a multi-talented modulator of chromatin architecture.

It has been a long trip from 1992, the year of the discovery of MECP2, to the present day. What is surprising is that some of the pivotal roles of MeCP2 were already postulated at that time, such as repression of inappropriate expression from repetitive elements and the regulation of pericentric heterochromatin condensation. However, MeCP2 performs many more functions. MeCP2 is a reader of epig...

The talented interferon-gamma

IFN-γ is an extraordinarily pleotropic cytokine. It can not only heighten both the innate and adaptive immune response against pathogens and tumors, but also has the ability to maintain immune homeostasis. Since the effects of IFN-γ are cell and tissue specific, it is important to consider the recent advances in IFN-γ signaling in the context of different diseases. To this end, we review the in...

Talented Imbeciles

The differential diagnosis of the type of feeblemindedness known as imbecility is by no means an artisan's job. No foot rule, scale, or point system has been devised or will ever be devised that will relieve the clinician of long, patient, and discriminating analysis in arriving at a diagnosis. An individual may be diagnosed or classified as an imbecile on the mental scale, on the intellectual ...

Gifted and talented students